Coumarin derivatives against amyloid-beta 40 – 42 peptide and <i>tau</i> protein

Abstract In preclinical studies, simple coumarins (scoparone, limettin) and furanocoumarins (imperatorin, xanthotoxin, bergapten) have already found to demonstrate procognitive abilities. This suggests that they hold antioxidative, anti-inflammatory inhibitory action towards acetylcholinesterase activities. However, little is known about their influence on the amyloidal structure formation, leading cause of Alzheimer’s disease (AD). vitro in cellulo assays were applied evaluate effect selected different stages Aβ40/42 tau protein aggregation. Kinetic analyses performed inhibiting abilities time. Limettin revealed most potent profile Aβ40 aggregation, however, all tested compounds presented low Aβ42 aggregation inhibition. Despite preliminary stage project, promising effects shown. coumarin scaffold can serve as a potential multitarget agent AD treatment, but further studies are required confirm this.